Understand how it works

How it acts, how it works

Interferon beta (IFNβ) and glatiramer acetate (GA) were the first immunomodulators approved to the treatment of relapsing-remitting multiple sclerosis (MS) and clinically isolated syndromes. Despite the enlargement of the therapeutic armamentarium, IFNβ and GA remain the most widely drugs and the therapeutic mainstay of MS. Objective: To review the mechanisms of action of IFNβ and GA and main c...

How It Works and Why It Matters

This paper provides simulation practitioners and consumers with a grounding in how discrete-event simulation software works. Topics include discrete-event systems; entities, resources, control elements and operations; simulation runs; entity states; entity lists; and entity-list management. The implementation of these generic ideas in AutoMod, SLX, and Extend is described. The paper concludes w...

Process evaluation: how it works.

Process evaluation helps us to understand the planning process. This predominantly qualitative approach explains how and why decisions are made and activities undertaken. The focus includes feelings and perceptions of program staff. The evaluator's ability to interpret and longitudinally summarize the experience of program staff and community members is critical. Techniques discussed include pa...

Seeing it happen and knowing how it works: how children understand the relation between perceptual causality and underlying mechanism.

Two experiments studied how 5- to 10-year-olds integrate perceptual causality with their knowledge of the underlying causal mechanism. Children learned about 2 devices by which a ball dropped into one end of a box made a bell ring at the other end, either immediately (contiguous mechanism) or after a delay (noncontiguous mechanism). When 1 ball was dropped first and a 2nd ball was dropped after...

Market integration: how it works